Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities

Table 4

Application of the proposed method for the determination of CDO, MBV, and their degradation products in binary mixtures.

Parameter	Conc. taken (µg/mL)		% found^a
	CDO	MBV	CDO	MBV
Binary mixture of CDO/MBV	3.0	81.0	99.82	99.87
	5.0	135.0	98.52	100.58
	7.0	189.0	98.65	99.08
Mean ± SD			98.99 ± 0.72	99.84 ± 0.75
% RSD			0.72	0.75
% error			0.41	0.43
	Conc. taken (µg/mL)		% found of CDO^a
	CDO	ACB
Binary mixture of CDO/ACB	100.0	2.0	99.08
	100.0	4.0	98.70
	100.0	8.0	99.12
	100.0	10.0	100.01
Mean ± SD			99.22 ± 0.56
% RSD			0.56
% error			0.32
	Conc. taken (µg/mL)		% found of MBV^a
	MBV	VER
Binary mixture of MBV/VER	200.0	2.0	100.20
	200.0	4.0	99.68
	200.0	8.0	100.03
	200.0	10.0	99.98
Mean ± SD			99.97 ± 0.22
% RSD			0.22
% error			0.08

Each result is the average of three separate determinations.