Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation

Table 1

Antimicrobial activity of the compounds 6a–6p (MIC, µg/mL).

Comp.	A	B	C	D	E	F	G	H	I
6a	200	200	200	200	200	50	100	50	100
6b	200	200	200	200	200	50	100	100	50
6c	100	100	200	200	200	200	100	200	50
6d	100	100	200	200	100	200	100	100	100
6e	200	100	200	200	400	200	100	100	100
6f	200	100	100	200	200	100	50	100	100
6g	200	100	100	200	200	100	100	100	200
6h	200	200	200	400	200	200	100	100	50
6i	200	100	200	200	400	50	100	100	200
6j	200	100	200	200	400	100	200	200	200
6k	200	200	100	200	400	100	200	200	200
6l	200	200	50	200	200	100	200	200	200
6m	200	200	200	200	100	50	100	100	100
6n	200	200	200	200	200	200	200	200	100
6o	200	200	200	200	200	100	200	200	200
6p	200	200	200	200	200	200	200	800	200
Ref. 1	25	50	50	25	25	—	—	—	—
Ref. 2	—	—	—	—	—	50	50	3.13	100

Reference 1: Chloramphenicol, Reference 2: Ketoconazole.
A: E. faecalis (ATCC 29212), B: K. pneumonia (ATCC 700603), C: P. aeruginosa (ATCC 27853), D: E. coli (ATCC 35218), E: E. coli (ATCC 25922), F: C. albicans (ATCC 90028), G: C. glabrata (ATCC 90030), H: C. krusei (ATCC 6258), I: C. parapsilosis (ATCC 7330).