Research Article
Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation
Table 2
% AChE inbition of the compounds 6a–6p and IC50 values.
| | Compounds | % AChE Inhibition | IC50 (mM) | | 1 mM | 0.1 mM |
| | 6a | 3.45 ± 5.10 | — | | | 6b | 7.19 ± 8.45 | — | | | 6c | — | — | | | 6d | — | — | | | 6e | 10.16 ± 10.12 | — | | | 6f | 2.86 ± 2.15 | — | | | 6g | 2.03 ± 3.21 | — | | | 6h | 7.28 ± 4.69 | — | | | 6i | 8.63 ± 3.25 | — | | | 6j | 57.04 ± 10.65 | 17.09 ± 2.3 | 0.84 ± 5.36 | | 6k | 37.09 ± 5.16 | 27.78 ± 5.12 | | | 6l | 29.59 ± 11.23 | 5.39 ± 2.11 | | | 6m | 58.79 ± 5.61 | 49.65 ± 6.49 | 0.13 ± 3.74 | | 6n | 43.96 ± 5.84 | 40.58 ± 5.89 | | | 6o | 41.96 ± 6.89 | 40.52 ± 7.36 | | | 6p | 44.68 ± 2.68 | 42.92 ± 3.55 | | | Donepezil | 98.24 ± 1.87 | 92.23 ± 2.62 | 0.054 ± 0.002 (µM) |
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ND: Not determined. (unpaired Student’s test between test compound and Donepezil).
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