Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone

Table 1

Analgesic activities of test compounds.

Comp. number	Comparative analgesic potency to aspirin after time in minutes
	30 min	60 min	90 min
HBOA	1.16 ± 0.03	1.88 ± 0.09	1.10 ± 0.16
TC-2	0.70 ± 0.09	1.55 ± 0.12	0.55 ± 0.08
TC-3	0.37 ± 0.07	1.88 ± 0.13	2.14 ± 0.14
TC-4	0.35 ± 0.03	0.80 ± 0.07	0.87 ± 0.13
TC-5	0.91 ± 0.05	1.12 ± 0.08	1.45 ± 0.15
TC-6	0.15 ± 0.04	0.45 ± 0.09	0.56 ± 0.09
TC-7	1.01 ± 0.06	1.20 ± 0.12	1.35 ± 0.13
TC-8	0.68 ± 0.07	0.88 ± 0.11	1.98 ± 0.14
TC-9	0.60 ± 0.05	0.91 ± 0.10	1.81 ± 0.21
TC-10	0.98 ± 0.08	0.40 ± 0.7	0.31 ± 0.08
Aspirin	1.00	1.00	1.00

All results were significantly different from the standard and normal control. Value at = 0.05.