Review Article
Magnetic Solid Phase Extraction Applied to Food Analysis
Table 1
Experimental MSPE conditions used for analysis of milk samples.
| Analyte | Amount of liquid sample | Magnetic material coating | Eluent volume | Eluent | Technique | Limit of detection | Recovery | References |
| Sulfonamides | 10.0 mL | Fe3O4/silica/poly(methacrylic acid-co-ethylene glycol dimethacrylate) | 1.0 mL | Acetone with 5% ammonia (v/v) | LC-MS/MS | 0.5–49.5 ng/L | 87.6–115.6% | [50] |
| Fluoroquinolones | 2.0 mL | Fe3O4-ethylene glycol, ethylene diamine, ammonium acetate | 1.0 mL | MeOH (7.0% ammonium) | HPLC-UV | 1.8–3.2 ng/g | 94.0–124.4% | [56] |
| Estrogens | 10.0 mL | MMIP(Fe3O4@SiO2)-ethylene glycol dimethacrylate | 7.0 mL | Acetic acid/methanol (0.5 mol/L) | HPLC-UV | 1.5–5.5 ng/g | 77.3–95.2% | [55] |
| Endocrine disruptors | 3.0 mL | Fe3O4@SiO2@C18 | 2.3 mL | n-Hexane | GC-MS | 0.1–0.3 µg/L | 81.0–107.0% | [45] |
| Melamine | 20.0 mL | MMIP melamine-methacrylic acid-ethylene glycol dimethacrylate-Fe3O4 | 0.5 mL × 6 | Methanol-acetic acid | LC-MS/MS | 2.6 ng/mL | 88.0–95.8% | [51] |
| Aflatoxin M1 | 10.0 mL | Hydrophobic oleic acid modified Fe3O4 nanoparticles | 3.0 mL | Acetonitrile | Spectrofluorimetry | 13.0 ng/L | 91.3–99.5% | [65] |
| Lead | 100.0 mL | CaFe2O4-3-aminopropyl-triethoxysilane-phthalic anhydride | 3.0 mL | Nitric acid 1.0 mol/L | AAS | 0.78 µg/L | 98.2% | [33] |
| Lead and cadmium | 50.0 mL | 1-(2-Pyridylazo)-2-naphthol-modified Fe3O4/TiO2 | 1.0 mL | Nitric acid 1.59 mol/L | AAS | 1.21 mg/L Pb(II) 0.21 mg/L Cd(II) | 96.9–101.6% Pb(II) 96.5–100.7% Cd(II) | [36] |
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Antibiotics, hormones, packing additives, mycotoxins, and Metal ions. MMIP: magnetic molecularly imprinted polymer.
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