Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents

Table 2

Antibacterial activity of the thiosemicarbazone derivatives (MIC values in µg/mL).

Compound	A	B	C	D	E	F	G	H	I
1	400	200	400	400	400	400	400	400	200
2	100	200	1600	1600	800	1600	1600	400	400
3	400	400	400	800	400	400	400	400	400
4	400	400	400	400	400	400	800	400	400
5	400	100	400	400	400	400	400	400	400
6	400	400	400	400	400	400	400	400	400
7	400	400	400	800	400	400	800	400	200
8	400	400	400	800	400	400	800	400	200
9	400	400	400	400	400	400	800	400	200
10	400	400	400	400	400	400	400	400	200
11	400	100	400	800	400	400	400	400	200
12	400	200	400	400	400	400	400	400	200
Chloramphenicol	100	200	200	100	200	200	100	25	Nt
Rifampicin	Nt	Nt	Nt	Nt	Nt	Nt	Nt	Nt	25

A: S. aureus (ATCC 25923), B: E. faecalis (ATCC 29212), C: E. faecalis (ATCC 51922), D: L. monocytogenes (ATCC 1911), E: K. pneumoniae (ATCC 700603), F: P. aeruginosa (ATCC 27853), G: E. coli (ATCC 35218), H: E. coli (ATCC 25922), and I: M. tuberculosis H37Rv.
Nt: not tested.