Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives

Table 1

Antiproliferative activities (IC₅₀) of compounds 19–30 against human cancer cell lines.

Compd.	Cell lines (IC50, μM)
	Hela	A-549	ECA-109
19	6.75 ± 0.40	11.29 ± 1.60	16.65 ± 1.98
20	4.06 ± 0.06	14.74 ± 2.68	8.23 ± 1.46
21	7.22 ± 1.72	16.72 ± 1.56	9.51 ± 1.22
22	11.58 ± 1.05	12.92 ± 1.17	12.26 ± 0.99
23	4.78 ± 0.67	13.34 ± 2.05	2.13 ± 0.35
24	15.03 ± 2.01	33.28 ± 4.35	8.74 ± 1.22
25	8.99 ± 1.21	20.00 ± 2.05	8.19 ± 0.75
26	5.21 ± 0.70	70.89 ± 5.33	2.60 ± 0.36
27	93.17 ± 5.00	97.42 ± 9.21	12.80 ± 1.98
28	>212	74.56 ± 8.73	153.35 ± 14.36
29	61.12 ± 6.85	28.19 ± 2.26	162.90 ± 11.78
30	>194	>194	>194
DDP	17.50 ± 0.83	30.89 ± 1.44	12.73 ± 0.70

Values presented are means of three experiments.