Ligand Synthesis Catalyst and Complex Metal Ion: Multicomponent Synthesis of 1,3-Bis(4-phenyl-[1,2,3]triazol-1-yl)-propan-2-ol Copper(I) Complex and Application in Copper-Catalyzed Alkyne-Azide Cycloaddition

Table 1

Synthesis of triazole 6 catalyzed by copper complex 4.

Entry	Catalyst ratio (% mol)	Solvent	% yield
1	0.5	CH2Cl2	80
2	1.0	CH2Cl2	89
3	2.5	CH2Cl2	100
4	5.0	CH2Cl2	100
5	0.5	H2O	35
6	1.0	H2O	43
7	2.5	H2O	100
8	5.0	H2O	100
9	0.5	Acetone	40
10	1.0	Acetone	60
11	2.5	Acetone	100
12	5.0	Acetone	100
13	0.5	THF	45
14	1.0	THF	70
15	2.5	THF	95
16	5.0	THF	100
17	0.5	DMF	46
18	1.0	DMF	69
19	2.5	DMF	96
20	5.0	DMF	100
21	0.5	AcOEt	30
22	1.0	AcOEt	60
23	2.5	AcOEt	93
24	5.0	AcOEt	96
25	0.5	MeOH	40
26	1.0	MeOH	50
27	2.5	MeOH	96
28	5.0	MeOH	100
29	2.5	EtOH	96
30	5.0	EtOH	100
31	2.5	nPrOH	94
32	5.0	nPrOH	100
33	2.5	CHCl3	94
34	5.0	CHCl3	100
35	2.5	CH3CN	93
36	5.0	CH3CN	100
37	2.5	Et2O	94
38	5.0	Et2O	100