Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity<i> In Vitro</i>

<div>The antiproliferative activity of drugs (<b>2</b>–<b>4</b> and the standard antitumor drug, cisplatin) was evaluated using the clonogenic assay against (a) human MDA-231 breast cancer cell line, (b) human MCF-7 breast cancer cell line, and (c) human K562 leukemia cell line. The surviving fraction was calculated as number of colonies after treatment/[number of seeded cells (200 cells) × plating efficiency (PE)], where PE = number of colonies/[number of seeded cells (200 cells) × 100%].</div>

Journal of Chemistry

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Figure 1

Figure 1: Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity<i> In Vitro</i> 

Figure 1 | Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro 