Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro

Table 2

MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) results, the values shown are .

Entry	Compound	Compound number	MDA-231	MCF-7	K562
1	DFMPB	1	(After 24 h)^+	(After 24 h)^+	(After 48 h)^+
			30.7 µg/mL	29.2 µg/mL	25.1 µg/mL
			136.27 µM	129.61 µM	110.9 µM
2	[Pd(DFMPB)Cl2]	2	(After 24 h)^+	(After 24 h)^+	(After 48 h)^+
			31.1 µg/mL	28.8 µg/mL	23.9 µg/mL
			63.83 µM	71.53 µM	59.36 µM
3	[Pd(DFMPB)(CH3CN)2](BF4)2	3	No effect	(After 72 h)^+	(After 48 h)^+
				50.1 µg/mL	43.6 µg/mL
				85.29 µM	74.22 µM
4	[Pt(DFMPB)Cl2]	4	(After 48 h)^+	(After 48 h)^+	(After 48 h)^+
			42.8 µg/mL	44.6 µg/mL	35.4 µg/mL
			87.12 µM	90.79 µM	72.1 µM
5	Cisplatin		(After 48 h)^+	(After 24 h)^+	(After 48 h)^+
			43.0 μg/mL	40.1 µg/mL	25.9 µg/mL
			143.31 µM	133.65 µM	86.32 µM

The results are shown in terms of IC₅₀ values (the concentration needed to inhibit 50% of the cellular proliferation). For comparison purposes, the cytotoxicity of cisplatin, a standard antitumor drug was tested under the same conditions.
⁺The time it took for the drug to affect cell viability.
After 72 h of drug addition, the drug killed at most 15% of the cells at 50 μg/mL.