Research Article
Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates
Table 2
Optimisation of [11C]1 synthesis using alternative bases.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
aIsopropanol (1 equiv., 22 µmol), BzCl (3 equiv.), TBAI (1–3 equiv.), and base (1–3 equiv.) in 500 μL DMF reaction time 5 mins from EOD. bThe nonisolated radiochemical yield determined by radio-HPLC analysis of the crude product. cReaction time of 10 mins from EOD.d. |