Synthesis and Evaluation of the Antibacterial and Antioxidant Activities of Some Novel Chloroquinoline Analogs

Table 5

Drug-likeness predictions of compounds 5–8 and 12 computed by SwissADME.

Compounds	Formula	Mol. Wt. (g/mol)	NRB	NHA	NHD	TPSA (A^°2)	LogP (cLogP)	Lipinski’s rule of five violation
5	C10H4Cl2N2	223.06	0	2	0	36.68	2.13	0
6	C10H6Cl2N2O	241.07	1	2	1	55.98	1.85	0
7	C11H8ClNO2	221.64	2	3	0	39.19	2.36	0
8	C12H10ClNO2	235.67	3	3	0	39.19	2.37	0
12	C10H5ClN2	188.61	0	2	0	36.68	1.91	0
Vosaroxin	C18H19N5O4S	401.45	5	9	2	136.13	0.963	0

NHD: number of hydrogen donors; NHA: number of hydrogen acceptors; NRB: number of rotatable bonds; and TPSA: total polar surface area.