Synthesis and Evaluation of the Antibacterial and Antioxidant Activities of Some Novel Chloroquinoline Analogs

Table 6

ADME predictions of compounds 5–8 and 12 computed by SwissADME and PreADMET.

Compounds	Chemical formula	Skin permeation value (log Kp) cm/s	GI absorption	BBB permeability	Inhibitor interaction (SwissADME/PreADMET)
					P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
5	C10H4Cl2N2	−5.18	High	Yes	No	Yes	Yes	No	No	No
6	C10H6Cl2N2O	−5.88	High	Yes	No	Yes	Yes	No	No	No
7	C11H8ClNO2	−5.82	High	Yes	No	Yes	Yes	No	No	No
8	C12H10ClNO2	−5.64	High	Yes	No	Yes	Yes	No	No	No
12	C10H5ClN2	−5.41	High	Yes	No	Yes	No	No	No	No
Vosaroxin	C18H19N5O4S	−8.98	High	No	Yes	Yes	No	No	No	No

GI: gastrointestinal; BBB: blood–brain Barrier; P-gp: P-glycoprotein; CYP: cytochrome-P.