Research Article
Synthesis and Evaluation of the Antibacterial and Antioxidant Activities of Some Novel Chloroquinoline Analogs
Table 6
ADME predictions of compounds 5–8 and 12 computed by SwissADME and PreADMET.
| Compounds | Chemical formula | Skin permeation value (log Kp) cm/s | GI absorption | BBB permeability | Inhibitor interaction (SwissADME/PreADMET) | P-gp substrate | CYP1A2 inhibitor | CYP2C19 inhibitor | CYP2C9 inhibitor | CYP2D6 inhibitor | CYP3A4 inhibitor |
| 5 | C10H4Cl2N2 | −5.18 | High | Yes | No | Yes | Yes | No | No | No | 6 | C10H6Cl2N2O | −5.88 | High | Yes | No | Yes | Yes | No | No | No | 7 | C11H8ClNO2 | −5.82 | High | Yes | No | Yes | Yes | No | No | No | 8 | C12H10ClNO2 | −5.64 | High | Yes | No | Yes | Yes | No | No | No | 12 | C10H5ClN2 | −5.41 | High | Yes | No | Yes | No | No | No | No | Vosaroxin | C18H19N5O4S | −8.98 | High | No | Yes | Yes | No | No | No | No |
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GI: gastrointestinal; BBB: blood–brain Barrier; P-gp: P-glycoprotein; CYP: cytochrome-P.
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