An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study

Table 1

A comparison between the examples of the previous reports and the present work.

Entry	Catalyst	Solvent	Temperature (°C)	Time (h)	Yield (%)	Type of workup	Ref
1	EDC/HOBT	DCM	R.T	12	80	Precipitation	[20]
2	TEA	Toluene	100	24	65.3	Extraction	[21]
3	TEA	DCM	−5	3.5	67.3	Extraction	[21]
4	DBU	n-butanol	40	18	87.6	Precipitation	[22, 23]
5	DBU	n-butanol	45	Not stated	85	Precipitation	[24]
6	DBU	n-butanol	40	20	93	Precipitation	[25]
7	DBU	Ethanol	R.T	6	50	Precipitation	[26]
8	HOBT	DCM	R.T	12	70	Extraction	[27]
9	DBU	ACN	40	6	72	Precipitation	[28]
10	DBU	—	R.T	11	95.1	Precipitation	This work