Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box-Behnken Design
Table 6
Results of pharmacokinetic study after oral administration of EOE and EOP formulation.
Pharmacokinetic parameters
Treatment
EOE (250 mg/kg)
EOP (∼250 mg/kg)
(μg/ml)
2.72 ± 0.147
5.14 ± 0.164
(h)
3.04 ± 0.004
6.1 ± 0.005
AUC0-t (μg/ml h)
29.91 ± 0.18
77.68 ± 0.15
AUC0-∞ (μg/ml h)
31.84 ± 0.11
86.42 ± 0.17
t1/2ka (h)
1.017 ± 0.22
4.08 ± 0.27
V/F (mg/kg)/(μg/ml)
125.48 ± 0.029
37.55 ± 0.035
CL/F (mg/kg)/(μg/ml)/h
15.70 ± 0.24
5.79 ± 0.17
The information is shown as mean ± SD values (n = 6).