On the Role of Optimal Counseling and Antiviral Therapy on Controlling HCV among Intravenous Drug Misusers

Table 1

Model parameters and their baseline values.

Parameter description	Symbol	Units	Value (range)	Source
Relapse rate	𝛼	Per year	0.1 (0.01–0.3)	[9]
Infection rate	𝛽	Per year	0.1 (0.1834–0.2334)	[5]
Treatment rate	𝛾	Per year	0.02 (0.01–0.4)	[1]
Abstinence ratio	𝑝	—	0.5 (0.01–0.6)	[9]
Modification factor	𝜔	—	0.5 (0.1–1.0)	[9]
1/treatment duration	𝜙	Per year	1.5 (0.9–1.992)	[9]
Natural mortality rate	𝜇	Per year	0.0142 (0.01-0.02)	[9]
New injector entrance rate	Λ	IDUs per year	250	Estimated
Average number of needle sharing partners for individuals in class 𝐼	𝑐	IDUs per year	5.0 (1–10)	[9]
Partner acquisition for individuals in class 𝐵	𝜃	IDUs per year	3.0 (1–10)	[9]
Proportion of infections spontaneously clear	𝛿	—	0.26 (0.01–0.26)	[9]
Proportion of infections cured by treatment for class 𝐴	1−𝑞	—	0.6 (0.5–0.625)	[9]
Proportion of infections cured by treatment for class 𝐵	1−𝜅	—	0.5 (0.5–0.625)	[9]
Proportion of relapse into class 𝐼	𝑓	—	0.3 (0–0.3)	[9]