2D-QSAR Study of Indolylpyrimidines Derivative as Antibacterial against Pseudomonas aeruginosa and Staphylococcus aureus: A Comparative Approach

Table 1

Structures of indolylpyrimidines and their antibacterial activity used for the QSAR studies.

Compound number	R1	R2	Zone of inhibition against Pseudomonas aeruginosa in mm (PAantibact)	Zone of inhibition against Staphylococcus aureus in mm (SAantibact)
4a	OH	H	13	16
4b	OH	p-NH2	24	26
4c	OH	p-Br	19	20
4d	OH	p-Cl	18	19
4e	OH	o,p-OH	14	14
4f	OH	p-F	17	18
4g	OH	p-CH3	13	10
4h	OH	p-OCH3	17	21
4i	OH	p-OH	11	16
4j	OH	p-NO2	23	22
5a	SH	H	12	13
5b	SH	p-NH2	18	19
5c	SH	p-Br	15	16
5d	SH	p-Cl	16	17
5f	SH	p-F	14	19
5g	SH	p-CH3	10	21
5h	SH	p-OCH3	13	25
5j	SH	p-NO2	19	16
6a	NH2	H	11	10
6b	NH2	p-NH2	10	24
6c	NH2	p-Br	17	23
6d	NH2	p-Cl	15	19
6e	NH2	o,p-OH	13	16
6f	NH2	p-F	23	22
6g	NH2	p-CH3	13	14
6h	NH2	p-OCH3	25	29
6i	NH2	p-OH	13	21
6j	NH2	p-NO2	24	31