|
| Cell lines | Animal models | Effects | Suggested pathways/regulators | References |
|
T-lymphoblast (A3.01)
T-cell leukemia (Molt-4 )
Pancreatic adenocarcinoma (CaPan-2)
Non-small-cell lung adenocarcinoma (CaLu-3)
Colon adenocarcinoma (LS174T and T84)
Daudi (B-cell lymphoma) | Tumor xenografts | Inhibition of subcutaneous tumor growth | | Tresssler et al., 1994 [27] |
|
| Lymphoma cells (RAQ 117-H10) | Murine model of metastasis (BALB/c) | Increased survival of animals | | Tressler et al., 1994 [27] |
|
| Prostate cancer (DU145) | | Cell cycle arrest and induction of differentiation | |
Floryk and Huberman 2006 [28] |
|
| Neuroblastoma (LAN5, SHEP 5, and IMR32) | | Induction of differentiation and apoptosis | (i) GTP depletion (differentiation)
(ii) P53 (apoptosis) | Messina et al., 2004 [29] |
|
Multiple myeloma (RPMI8226 and RPMI8226-HAMcl )
Primary multiple myeloma cells | | Induction of apoptosis | (i) GTP depletion
(ii) Cytochrome c release
(iii) Caspase activation | Takebe et al., 2006 [30] |
|
| Imatinib and nilotinib resistant chronic myeloid leukemia (K562) | | Induction of apoptosis | | Drullion et al., 2012 [31] |
|
| Breast cancer (MDA-MB-231 and MCF-7) | | Induction of differentiation | PPARγ | Zheng et al., 2011 [32] |
|
Mouse colon adenocarcinoma (CT26 )
Melanoma (B16)
Human gastric adenocarcinoma (TMK1) | | Inhibition of tumor cell growth and angiogenesis | | Koehl et al., 2007 [33] |
|
Colon carcinoma (HT-29)
Prostate cancer (DU145) | | Reduction of cell adhesion | Beta 1 integrin | Engl et al., 2005 [34] |
|
WiDr colon adenocarcinoma
T cells | | Reduction of cell adhesion | | Leckel et al., 2003 [35] |
|
| Glioblastoma cells (U87) | BALB/c nude mice | Inhibition of tumor cell growth in xenograft model but not in vitro | MYC signaling | Domhan et al., 2008 [36] |
|
| Pancreatic cell lines (MiaPaCa and Panc-1) | | Sensitization of gemcitabine | TGF-beta-1 | Tuncyurek et al., 2007 [37] |
|
