Review Article
Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives
Table 1
Physicochemical properties of ascorbic acid derivatives.
| | | Ref |
| ASC-G | | | Solubility | 714 g/L at 19 ± 1°C |
*
| Surface tension | 71 mN/m (0.99 mg/mL) |
*
| Stability | Half-life at 50°C: >1 year at pH 4, 7, and 9 |
*
| Toxicity | Acute oral toxicity (LD50): 2500 mg/kg (Rat) |
*
| Acute dermal toxicity (LD50): >2000 mg/kg (Rat) |
| ASC-8 | | | Critical micelle concentration | 6 × 10-3 mol/L (pH2) | [1] | Hydrodynamic radius | 25.4 Å | [1] | Head group area | 57.6 Å2 | [1] | Aggregation number | 84 | [1] |
| ASC-P | | | Solubility | 5.6 mg/mL at 25 ± 0.1°C |
**
| Toxicity | Acute oral toxicity (LD50): 25000 mg/kg (Mouse) |
**
| Acute dermal toxicity (LD50): >3000 mg/kg (Guinea pig) |
| ASC-S | | | Solubility | Insoluble in water, soluble in ethanol |
***
|
| ASC-DP | | | Solubility | Insoluble in water |
****
| Stability | Stable in aqueous media at pH 4, 7, and 10 |
****
| Stable in methanol |
****
| Safety | Oral administration: up to 1.25 mg/kg body weight daily |
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*2-O-α-D-glucopyranosyl-L-ascorbic acid, Full Public Report National Industrial Chemicals Notification and Assessment Scheme, file no. STD/1056, 2003.
**
http://www.sciencelab.com/xMSDS-Ascorbyl_palmitate-9922973.
***
http://www.fao.org/ag/agn/jecfa-additives/details.html?id=43.
****Unpublished data.
*****
http://www.hc-sc.gc.ca/.
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