Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration
Figure 1
Uptake of FITC-oligonucleotides by intraperitoneal macrophages at 6 hrs after i.p. administration. Oligonucleotides were delivered using either (A) non-PEGylated or (B) PEGylated liposomes (LP), and macrophages were identified via APC-CD11b and PE-F4/80 staining. FACS plots are gated on APC-CD11b- and PE-F4/80-positive cells, and pooled peritoneal fluid of up to 3 mice was examined for each treatment group.
