Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration

Table 1

Quantitative analysis of the distribution of Alexa Fluor 750-conjugated oligonucleotides in tumours and major first-pass organs at 24 hrs following intraperitoneal administration in mice. Oligonucleotides were delivered using either non-PEGylated or PEGylated liposomes (LP). The fluorescent images are presented in Figures 2 and 3.

	Average percentage of the total fluorescence intensity detected
	Tumour	Liver	Kidney	Spleen
Non-PEGylated LP	7.5%	45.7%	15.7%	30.0%
PEGylated LP	65.9%	20.6%	7.8%	5.7%