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Journal of Drug Delivery
Volume 2011 (2011), Article ID 203676, 7 pages
doi:10.1155/2011/203676
Cell Uptake and Validation of Novel PECs for Biomedical Applications
1NNL, Institute of Nanoscience CNR, Street Arnesano, 73100 Lecce, Italy
2Scuola Superiore ISUFI, University of Salento, Street Arnesano, 73100 Lecce, Italy
3Hematology and Clinical Proteomics Unit, “Vito Fazzi” Hospital, University of Salento, Square Muratore, 73100 Lecce, Italy
4Dipartimento Ingegneria dell'Innovazione, University of Salento, Street Monteroni, 73100 Lecce, Italy
5Center of Biomolecular Nanotechnologies (CNB) of Italian Institute of Technology (IIT), Street Barsanti, 73010 Arnesano (Le), Italy
Received 8 April 2011; Revised 28 June 2011; Accepted 30 June 2011
Academic Editor: Philippe Maincent
Copyright © 2011 Ilaria E. Palamà et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- M. Jenkins, Biomedical Polymers, Woodhead Publishing, Cambridge, UK, 2007.
- T. M. Allen and P. R. Cullis, “Drug delivery systems: entering the mainstream,” Science, vol. 303, no. 5665, pp. 1818–1822, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- G. A. Hughes, “Nanostructure-mediated drug delivery,” Nanomedicine, vol. 1, no. 1, pp. 22–30, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Panyam and V. Labhasetwar, “Biodegradable nanoparticles for drug and gene delivery to cells and tissue,” Advanced Drug Delivery Reviews, vol. 55, no. 3, pp. 329–347, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. Kircheis, L. Wightman, and E. Wagner, “Design and gene delivery activity of modified polyethylenimines,” Advanced Drug Delivery Reviews, vol. 53, no. 3, pp. 341–358, 2001. View at Publisher · View at Google Scholar · View at Scopus
- C. E. Thomas, A. Ehrhardt, and M. A. Kay, “Progress and problems with the use of viral vectors for gene therapy,” Nature Reviews Genetics, vol. 4, no. 5, pp. 346–358, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- I. E. Palamà, S. Leporatti, E. De Luca, et al., “Imatinib-loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells,” Nanomedicine, vol. 5, no. 3, pp. 419–431, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. G. De Geest, R. E. Vandenbroucke, A. M. Guenther, et al., “Intracellularly degradable polyelectrolyte microcapsules,” Advanced Materials, vol. 18, no. 8, pp. 1005–1009, 2006. View at Publisher · View at Google Scholar · View at Scopus
- S. De Koker, B. G. De Geest, C. Cuvelier, et al., “In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules,” Advanced Functional Materials, vol. 17, no. 18, pp. 3754–3763, 2007. View at Publisher · View at Google Scholar · View at Scopus
- I. E. Palamà, A. M. L. Coluccia, A. D. Torre, et al., “Multilayered polyelectrolyte capsules and coated colloids: cytotoxicity and uptake by cancer cells,” Science of Advanced Materials, vol. 2, pp. 1–9, 2010.
- H. Ai, J. J. Pink, X. Shuai, D. A. Boothman, and J. Gao, “Interactions between self-assembled polyelectrolyte shells and tumor cells,” Journal of Biomedical Materials Research, Part A, vol. 73, no. 3, pp. 303–312, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Wang, C. He, Z. Tong, X. Liu, B. Ren, and F. Zeng, “Combination of adsorption by porous CaCO3 microparticles and encapsulation by polyelectrolyte multilayer films for sustained drug delivery,” International Journal of Pharmaceutics, vol. 308, no. 1-2, pp. 160–167, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Harada-Shiba, K. Yamauchi, A. Harada, I. Takamisawa, K. Shimokado, and K. Kataoka, “Polyion complex micelles as vectors in gene therapy—pharmacokinetics and in vivo gene transfer,” Gene Therapy, vol. 9, no. 6, pp. 407–414, 2002. View at Publisher · View at Google Scholar · View at Scopus
- S. Vinogradov, E. Batrakova, S. Li, and A. Kabanov, “Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells,” Bioconjugate Chemistry, vol. 10, no. 5, pp. 851–860, 1999. View at Publisher · View at Google Scholar · View at Scopus
- H. Cheng, Y. Y. Li, X. Zeng, Y. X. Sun, X. Z. Zhang, and R. X. Zhuo, “Protamine sulfate/poly(L-aspartic acid) polyionic complexes self-assembled via electrostatic attractions for combined delivery of drug and gene,” Biomaterials, vol. 30, no. 6, pp. 1246–1253, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Lankalapalli and V. R. M. Kolapalli, “Polyelectrolyte complexes: a review of their applicability in drug delivery technology,” Indian Journal of Pharmaceutical Sciences, vol. 71, no. 5, pp. 481–487, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. L. Lewis, M. M. Heitkemper, S. R. Dirksen, P. G. O'Brien, and L. Bucher, Medical-Surgical Nursing: Assessment and Management of Clinical Problems, Mosby, St. Louis, Mo, USA, 7th edition, 2008.
- N. Nafee, M. Schneider, U. F. Schaefer, and C. M. Lehr, “Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile,” International Journal of Pharmaceutics, vol. 381, no. 2, pp. 130–139, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- N. Kong, T. Jiang, Z. Zhou, and J. Fu, “Cytotoxicity of polymerized resin cements on human dental pulp cells in vitro,” Dental Materials, vol. 25, no. 11, pp. 1371–1375, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- F. Unger, M. Wittmar, and T. Kissel, “Branched polyesters based on poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide): effects of polymer structure on cytotoxicity,” Biomaterials, vol. 28, no. 9, pp. 1610–1619, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus