High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy

Scheme 2

Methodology for the metal ion coordination, drug loading, surface immobilization, and passivation of G4 PAMAM-OH dendrimers. Dendrimers in solution (a) are doped with Pt²⁺ ions (b). Indomethacin is then added to the solution (c). The conductive, drug-loaded dendrimers are then exposed to Au(111) (a) followed by C₈ flooding, (b), to obtain the surface-immobilized G4 PAMAM-OH-(Pt²⁺)_𝑛-(Indo)_𝑚.