Table 1: Targeting MAbs for THL and target tissue.

Targeting MAbTarget receptorExperimental model and target tissue

Murine OX26 [53]Rat TfR(a) Rat C6 or RG2 glioma in culture
(b) Rat C6-790 in cultures
(c) In vivo transport via rat BBB and rat brain cells (neuron and glial). Gene delivery
Rat 8D3 [54]Mouse TfRIn vivo transport via rat BBB and rat brain cells (neuron and glial). Gene delivery
Murine 8314 [60]Human IR(a) Human U87 glioma cultures
(b) In vivo transport via primate/human BBB and brain cells (neuron and glial). Gene delivery
8D3 + 8314 [23]Mouse TfR + human IR(a) Experimental human brain tumors in scid mice
(b) In vivo transport via mouse BBB and brain primate/human cells (neuron and glial). Gene delivery
Chimeric anti-TfR [55]Mouse TfR Gene delivery in mice
Humanized anti-IR [26]Human IR Gene delivery in humans