|Table 3: Tyrosine hydroxylase (TH) in brain and apomorphine-induced contralateral rotation after intravenous injection of gene therapy with TH expression plasmids.|
|Rx: single IV injection of TfRMAb-targeted THLs encapsulating the respective TH expression plasmid. *Mean ± S.E. (–6 rats per point). Statistically significant differences were determined by Student’s t-test.|
Clone 877 is the TH expression plasmid driven by the SV40 promoter. For details in the engineering of TH genomic vectors, clones prgTH2–TH4, please see Figure 5.
Difference with saline: a; b.
Difference with clone 877: c; d.
NA: not applicable.