Research Article
Modeling Drug-Carrier Interaction in the Drug Release from Nanocarriers
Table 1
Parameter estimates for simulations in Figure
3.
| Drug/Carriera | Mechanisms | Variables | Model parametersb | | | (10−21 J) |
| | | 1 mol% PEG | 0.494M | 0.014M | −0.97 |
CFTSL [24] | PEG addition | 3 mol% PEG | 1.568M | 0.026M | 0.83 | 4 mol% PEG | 1.273M | 0.039M | 2.18 | | | 10 mol% PEG | 2.785M | 0.089M | 4.77) |
| | | Vera-FBS | 2.268H | 0.092H | 4.71 |
Vera and Dox liposome [25] | Serum | Vera-HBS | 1.912H | 0.096H | 3.88 | Dox-FBS | 1.670H | 0.0037H | −10.4 | | Dox-HBS | 1.706H | 0.0056H | −12.6 | | Vera-in vivo | 4.561H | 0.08H | 11.5 | Lipid membrane | Vera-MLV | 3.360H | 0.04H | 10.2 | Dox-in vivo | 0.212H | 0.008H | −1.22 | | | Dox-MLV | 1.387H | 0.005H | −2.32) |
| | | pH 2.0 | 0.028H | — | — |
AmiodaroneLNC [26] | pH | pH 3.0 | 0.032H | 0.011H | 4.52 | pH 4.0 | 0.033H | 0.006H | 3.49 | pH 5.5 | 0.033H | 0.004H | −0.86 | | | pH 7.4 | 0.265H | 0.003H | −9.35) |
|
BSAPLLA [29] | Molecular weight | 16,000 | 0.719H | 0.025H | 0.41 | 51,000 | 0.754H | 0.02H | −3.3) |
|
IndomethacinPECL [27] | Coating | PLL-coated | 0.0182M | 0.202M | 11.8 | uncoated | 0.0156M | 0.203M | 11.8 |
|
|
aCF: carboxylfluorescein; TSL: thermosensitive liposome; Vera: verapamil; Dox: doxorubicin; FBS: fetal bovine serum; HBS: Hepes buffered saline; BSA: bovine serum albumin; PLLA: poly(L-lactide); PECL: poly-ε-caprolactone.
b and have different units in difference cases: M: minute−1 and H: hour−1.
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