Tumor Suppressor Gene-Based Nanotherapy: From Test Tube to the Clinic

Table 1

Tumor suppressor genes tested as cancer therapeutic in preclinical studies.

TSG	Cancer	Animal model	Therapeutic outcomes	Molecular events
E1A	Ovarian	Intraperitoneal tumor	Reduced abdominal tumor burden; increased animal survival	Apoptosis, reduced ascites, and cell cycle arrest
p53	Lung	Subcutaneous tumor; experimental lung metastasis	Tumor-growth inhibition; reduced extrapulmonary tumor nodules and increased animal survival	Cell cycle arrest, apoptosis, andantiangiogenesis
Fhit	Lung	Subcutaneous tumor; experimental lung metastasis	Tumor-growth inhibition; reduced extrapulmonary tumor nodules and increased animal survival	Cell cycle arrest and apoptosis
IL-24	Lung	Subcutaneous tumor; experimental lung metastasis	Tumor-growth inhibition; reduced extrapulmonary tumor nodules; increased animal survival	Cell cycle arrest, apoptosis, antiangiogenesis, and autophagy proimmune activity
Fus1	Lung	Subcutaneous tumor; experimental lung metastasis	Tumor-growth inhibition; reduced extrapulmonary tumor nodules; increased animal survival	Cell cycle arrest and apoptosis
BiKDD	Pancreas	Subcutaneous tumor; orthotopic tumor	Tumor-growth inhibition; reduced metastasis, increased animal survival	Apoptosis