Lipid Nanocapsule-Based Gels for Enhancement of Transdermal Delivery of Ketorolac Tromethamine

Table 3

Physical properties of nano lipid capsules of ketorolac tromethamine (RE₆₅% is released efficiency percent of drug until 65 min of release test) (results are mean ± SD).

Type of nanoparticles	Average size (nm)	Zeta potential (mV)	Drug loading efficiency (%)	RE65 (%)
S25O10W2.35L5	56.0±24.9	−3.3±0.7	38.6±2.5	44.4±1.7
S20O10W1.2L1.5	59.7±11.4	−1.6±0.4	13.5±0.4	40.6±3.4
S30O10W3.5L3.25	20.5±0.7	−3.7±0.3	36.2±3.1	43.2±1.5
S25O25W1.2L3.25	221.0±42.2	−1.9±0.1	28.9±0.4	25.0±0.2
S30O17.5W1.2L5	39.5±8.2	−1.8±0.1	34.0±0.7	24.4±0.0
S25O17.5W3.5L1.5	86.8±2.2	−3.9±0.4	23.0±1.5	38.6±0.0
S30O25W2.35L1.5	196.2±4.5	−3.3±0.6	29.8±2.5	26.7±0.0
S20O25W3.5L5	54.8±4.2	4.0±0.6	26.6±1.2	39.5±0.4
S20O17.5W2.35L3.25	60.5±12.8	−4.2±0.4	34.8±6.8	39.1±0.3
Optimized LNCs (S20O25W3.5L3.25)	102.7±0.8	−7.8±0.5	31.0±10.6	37.4±1.3