Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications
Figure 4
Synthetic schemes for PEG10,000-AD2-Ara-C4 (7) (a) and PEG10,000-AD2-AD4-Ara-C8 (8) conjugates (b). The antitumour agent 1-b-D-arabinofuranosylcytosine (Ara-C) was covalently linked to varying molecular weight –OH terminal PEGs through an amino acid spacer in order to improve the in vivo stability and blood residence time (reproduced from [22]).
