Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery

Figure 6

Mechanisms for cell entry of nucleic acid-liposome complexes. Two major pathways for interaction are by endocytosis or by direct fusion with the cell membrane. Complexes that enter the cell by direct fusion allow delivery of more nucleic acids to the nucleus because the bulk of the nucleic acids do not enter endosomes.