Utilisation of Nanoparticle Technology in Cancer Chemoresistance
Figure 1
Overview of chemoresistance emergence, using cisplatin as an example for a conventional chemotherapeutic drug. Intrinsic chemoresistance (a) demonstrates the presence of tumour cell colonies that possess the optimal genetic and phenotypic characteristics to withstand exposure to cytotoxic agent activity. These characteristics were present in such cells prior to initial chemotherapy exposure and hence the term intrinsic chemoresistance. In acquired chemoresistance (b), the tumour cell line develops chemoresistance due to mutational driving forces following prolonged exposure to chemotherapeutic agents.
