Research Article
Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate
Table 3
Response data obtained for the 3-factor Box-Behnken experimental design PLA-MAA nanoparticle formulations.
| Formulation number | Size (nm) | PdI value | DEE (%) | Yield (mg) |
| 1 | 258.2 | 0.255 | 5.0 | 69.65 | 2 | 309.8 | 0.371 | 6.6 | 70.45 | 3 | 211.1 | 0.237 | 5.1 | 54.60 | 4 | 238.2 | 0.365 | 4.0 | 63.80 | 5 | 239.5 | 0.289 | 8.9 | 84.00 | 6 | 286.3 | 0.277 | 8.8 | 86.20 | 7 | 308.4 | 0.413 | 7.0 | 67.50 | 8 | 227.3 | 0.297 | 4.0 | 64.20 | 9 | 274.8 | 0.388 | 5.6 | 56.85 | 10 | 1012.0 | 0.971 | 7.3 | 57.10 | 11 | 263.8 | 0.197 | 4.9 | 55.70 | 12 | 242.1 | 0.354 | 4.2 | 61.80 | 13 | 378.3 | 0.250 | 7.6 | 74.40 | 14 | 222.1 | 0.682 | 1.5 | 38.60 | 15 | 241.1 | 0.281 | 6.0 | 59.90 | Optimized 1 | 331.0 | 0.289 | 12 | 82.40 | Optimized 2 | 211.0 | 0.284 | 98 | 82.40 |
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