Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer: Preparation and In Vitro Assessment
Figure 4
: (a) Dose-response cytotoxicity of DOX-loaded PEI-enhanced HSA nanoparticles as compared to free DOX administered to MCF-7 breast cancer cells in log-phase culture after 48 hrs of treatment with different concentrations of DOX. (b) Time of exposure: cytotoxicity resulting from DOX-loaded PEI-enhanced HSA nanoparticles versus free DOX over 96 hrs was measured. The concentration of DOX administered was 1 μg/mL to MCF-7 breast cancer cells. Percentage of viable cells was assessed by an MTS assay and then compared to untreated cells in the control wells (mean ± S.D., ).