Multifunctional NP-based systems for tumor targeting, delivery and imaging. These innovative NPs comprise nucleic acids, aptamers and anticancer drug molecules for delivery to the target tissue. Depending on the targeting mechanism, they can be on the surface or inside the NPs. Responsive NPs/molecules can also trigger reaction upon external stimuli through the functionality of valuable tumor markers, peptides, polymers and antibodies that can used to improve NP circulation, effectiveness and selectivity. Multifunctional systems can carry reporter molecules tethered to the particle surface and employed as tracking and/or contrast agents.
