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Journal of Drug Delivery
Volume 2012 (2012), Article ID 842785, 11 pages
http://dx.doi.org/10.1155/2012/842785
Research Article

Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga

1Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka 560-8531, Osaka, Japan
2Department of Materials, ETH, Wolfgang-Pauli-Straße 10, 8093 Zürich, Switzerland
3Department of Pathogenomics, Graduate School of Medicine, Ehime University, Shitsukawa, Toon 791-0295, Ehime, Japan
4Department of Bone and Joint Surgery, Graduate School of Medicine, Ehime University, Shitsukawa, Toon 791-0295, Ehime, Japan
5Integrated Center for Science Shigenobu Station, Ehime University, Shitsukawa, Toon 791-0295, Ehime, Japan
6Department of Materials Science and Biotechnology, Graduate School of Science and Engineering, Ehime University, 3 Bunkyo-cho, Matsuyama 790-8577, Ehime, Japan

Received 30 September 2012; Accepted 21 November 2012

Academic Editor: Andreas G. Tzakos

Copyright © 2012 Keita Hayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material contains (i) data on the cytotoxicity and binding affinity of free ESA and EV for normal cells and for cancer cells; and (ii) a comparison of the effect of free ESA on the cell viabilities of osteosarcoma and carcinoma cells.

  1. Supplementary Material