Combination Drug Delivery Approaches in Metastatic Breast Cancer

Table 4

Combination drug delivery systems based on dendrimers.

Carrier composition	Therapeutics	Indication	Status	Targeting	References
G5 PAMAM dendrimer	Antisense-miRNA21 + 5-FU	Glioblastoma	In vitro	Active; miRNA overexpression	[78]
Aptamer-G4 PAMAM dendrimer conjugates	Unmethylated CpG-ONTs + Doxorubicin	Prostate cancer	In vivo	Active; a single-strand DNA-A9 PSMA, RNA aptamer hybrid	[79]
Dendritic PEG	Paclitaxel + alendronate	Cancer bone metastases	In vivo	Active; Bone metastasis	[80]
RGDfK-G3 Poly-lysine dendrimer	Doxorubicin + siRNA	Glioblastoma	In vitro	Active; 𝛼𝑣𝛽3 integrin	[81]
Folate-G5 poly-propyleneimine dendrimer with ethylenediamine core	Methotrexate + all-trans-retinoic acid	Leukemia	In vitro	Active; folate receptor	[82]

PAMAM: poly (amidoamine); PEG: polyethylene glycol; PSMA: prostate-specific membrane antigen; ONT: oligonucleotides; 5-FU: 5-fluorouracil.