A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
Figure 4
pH-dependent release of drug-loaded micelles. (a) Crosslinked and uncrosslinked BB4007431 micelles were diluted below the CMC and dialyzed for 6 hours in 10 mM phosphate buffer at different pHs. The amount of drug retained before and after dialysis was quantified by HPLC. (b) Crosslinked BB4007431 micelles were diluted below the CMC and dialyzed for 6 hours in either 10 mM phosphate buffer, or PBS, at different pHs. Drug content remaining was quantified by HPLC as above.
