Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis
Figure 1
Design and preparation of M/D-CTX-Fcs. (a) Schematic diagrams of monomeric and dimeric CTX-Fcs and the multivalent display of M-CTX-Fc on the surface of ZZ-BNCs. (b) Reduced and nonreduced forms of M/D-CTX-Fcs. M/D-CTX-Fcs were subjected to SDS-PAGE and western blotting. Anti-human-IgG-Fc antibody reacted with the purified M/D-CTX-Fcs without significant degradation. Arrows indicate the purified protein. β-ME: beta-mercaptoethanol; WB: western blotting; CBB: Coomassie Brilliant Blue staining.
