Targeted Antiepidermal Growth Factor Receptor (Cetuximab) Immunoliposomes Enhance Cellular Uptake In Vitro and Exhibit Increased Accumulation in an Intracranial Model of Glioblastoma Multiforme
Figure 4
FACS analysis showing enhanced cellular binding of α-hEGFR-IL’s in U87 mg (a) and U251 mg (b) cell lines. The targeting efficiency of the α-hEGFR-IL’s (green histograms) was evaluated by comparing mean fluorescence intensities (MFI) with hIgG-IL’s (orange histograms), or naked liposome (blue histograms) and cells not exposed to liposomes (black histograms). (c), (d) Comparison of the liposomal MFI of U87 mg (c) and U251 mg (d). , Lp, liposome.
