Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 3

Irritation scores and interpretations used in HET-CAM test.

Effect/time (min)	Score			Cumulative score	Irritation assessment
	0.5	2	5	0–0.9	None
Hyperemia	5	3	1	1.0–4.9	Slight
Hemorrhage	7	5	3	5.0–8.9	Moderate
Clotting/coagulation	9	7	5	9.0–21.0	Severe