Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 5

Effect of drug loading on PS and PI of CSNs.

CS : TPP weight ratio	PS of drug loaded NPs (nm)	PI	PS of blank NPs (nm)
6 : 1	250.3±2.627	0.313±0.009	247.5±3.379
5 : 1	383.2±3.668	0.385±0.006	355.3±6.102
4 : 1	490.9±4.804	0.442±0.030	446.7±9.628

Values are expressed as mean ± standard deviation, 𝑛=3.
CS: chitosan; TPP: tripolyphosphate; PS: particle size; NPs: nanoparticles; PI: polydispersity index; CSNs: chitosan nanoparticles.