Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting

Figure 4

Strategies for intracellular delivery. Steps for intracellular delivery: (1) Stimuli-sensitive activation/unmasking of internalization moiety, (2) Cancer cell-specific endocytosis, (3) Endosomal escape and/or therapeutic agent release after activation of fusogenic peptides or lipids, (4) Binding to the highly negative mitochondrial outer membrane for mitochondria targeting. Legends are the same as in Figure 1.