Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting

Table 1

Examples of multifunctional liposomal nanocarriers.

Encapsulated agent	Targeting ligand	Development stage	References
Doxorubicin	None	Approved (Doxil/Caelyx)	[13]
Vincristine	None	Approved (Marqibo)	[14]
Paclitaxel	None	Approved (Lipusu)	[15]
Cytarabine and daunorubicin	None	Phase I (CPX-351)	[24]
Irinotecan and floxuridine	None	Phase I (CPX-1)	[25]
PKN3 siRNA	None	Phase I (Atu-027)	[26]
Irinotecan	None	Phase I (NL CPT-11)	[27]
Doxorubicin	Stomach cancer-specific anti-GAH mAb	Phase I (MCC-465)	[28]
Oxaliplatin	Transferrin	Phase II (MBP-426)	[29]
Liposomal p53 DNA and docetaxel	Anti-Transferrin receptor scFv	Phase I (SGT53-01)	[30]
Doxorubicin	Thermoresponsive liposomes	Phase III (ThermoDox)	[31]
Doxorubicin	Cancer-specific 2C5 mAb	preclinical	[32]
Doxorubicin	Anti-CD22 mAb	preclinical	[33]
Paclitaxel	Anti-HER2 mAb	preclinical	[34]
Vincristine	mBAFF	preclinical	[35]
Oxaliplatin	Transferrin	preclinical	[36]
Daunorubicin	Transferrin and mannose	preclinical	[37]
Vinorelbine	NSCLC-specific peptide	preclinical	[38]
Doxorubicin	Metastasis-specific peptide	preclinical	[39]
Doxorubicin	MMP-2/9 detachable PEG	preclinical	[40]
Irinotecan	Folic acid	preclinical	[41]
Doxorubicin	Estrone	preclinical	[42]
Etoposide	Chondroitin sulfate	preclinical	[43]