Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting

Table 2

Examples of ligands used for targeting of liposomal nanocarriers.

Type of ligand	Ligand	Target	Reference(s)
Antibody	Anti-HER2	HER2 receptor overexpressed by cancer cells	[34, 98, 100]
	Anti-CD19	CD19 overexpressed in B cell Lymphoma	[101]
	Nucleosome-specific 2C5 mAb	Cancer cells surface-bound nucleosomes	[32, 102]
Protein	Transferrin	Transferrin receptor overexpressed by cancer cells	[36, 103]
	Interleukin 13 (IL-13)	IL-13 receptor overexpressed in human gliomas	[104]
Peptide	Octreotide	Somatostatin receptor type 2 overexpressed by cancer cells	[105, 106]
	LHRH-derived peptide	LHRH receptors overabundant on cancer cells	[107]
	Arg-Gly-Asp (RGD)	αVβ3overexpressed by endothelial tumor cells	[108–110]
Small molecule	Folate	Folate receptor on cancer cells	[41, 111]
	Estrone	Estrogen receptors overexpressed in ovarian and breast cancers	[42, 112]
	Anisamide	Sigma receptors overexpressed by cancer cells	[113]
Sugar	Mannose	Dendritic cells and macrophages to induce an immune response	[114, 115]
	Lactose	Asialoglycoprotein receptors overexpressed by hepatocellular carcinomas	[116]

HER2: human epidermal growth factor receptor 2, mAb: monoclonal antibody, LHRH: luteinizing hormone releasing hormone.