Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells
Figure 2
Strategies to prepare HA-coated nanocarriers. A schematic representation. (a) HA binding to preformed nanocarrier. Amidation reaction between HA-carboxyl group and aminoreactive group of lipid on the liposome surface. (b) Synthesis of HA-PE conjugates and following preparation of HA-coated lipid nanocarrier for postinsertion. (i) Reductive amination at the HA reducing end. (ii) Amidation reaction between HA-carboxyl group and aminoreactive group of lipid (PE).
