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Receptor | Designation | Function |
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3. Type-1 integral membrane proteins | | |
3.1. DEC205 | CD205 | Homologous to the mannose receptor. |
Ly 75 | Expressed on DCs and thymic epithelial cells. Targeting DEC205 induces an array of immune responses. |
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4. Scavenger receptors | | |
4.1. Scavenger receptor | | Expressed on macrophages. Bind to modified low density lipoproteins (LDL) by oxidation (oxLDL) or acetylation (acLDL). Bind to CD68, macrosialin, mucins, and LOX-1. Targeting of scavenger receptors induces immune responses in mice. |
4.1.1. Scavenger receptor class A | SR-A1 | Expressed on macrophages as a trimer. |
SR-A2 | Members include SCARA1 (MSR1), SCARA2 (MARCO), SCARA3, SCARA4 (COLEC12), and SCARA5. |
4.1.2. Scavenger receptor class B | SR-B1 | Consists of 2 transmembrane units. Members include SCARB1, SCARB2, and SCARB3 (CD36). |
4.1.3. Scavenger receptor class C | SR-B1 | Consists of a transmembrane region in which the N-terminus is located extracellularly. |
4.2. DC-asialoglycoprotein receptor (DC-ASGPR) | | A lectin-like scavenger receptor. Expressed on monocyte derived DCs (CD14+CD34+), tonsillar interstitial-type DCs, and granulocytes. Targeting DC-ASGPR induces suppressive responses. |
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5. F4/80 receptor | | Expression restricted to macrophages. Murine homolog of the epidermal growth factor-like module containing mucin-like hormone receptor-1 protein encoded by the EMR1 gene. |
5.1. FIRE | | Expressed on CD8−CD4+ and CD8−CD4− immature DCs, and weakly on monocytes and macrophages. Targeting FIRE stimulates immune responses in mice. |
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6. DC-specific transmembrane protein (DC-STAMP) | | Expressed on DCs and activated blood DCs. Targeting DC-STAMP results in immunosuppressive responses in some studies and in other studies stimulates strong cellular responses. |
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7. FcR | | Links humoral and cellular immune (Fc Receptor) responses, links innate and adaptive immune responses by binding pathogens and immune complexes, and stimulates T cells. Targeting FcR is a novel vaccine strategy for stimulating immune responses. |
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