The Signature Sequence Region of the Human Drug Transporter Organic Anion Transporting Polypeptide 1B1 Is Important for Protein Surface Expression

<div>Uptake of 0.1 <i>μ</i>M [<sup>3</sup>H]E3S at 37°C between 0.5 and 10 min measured in HEK293T cells transiently transfected with OATP1B1-pcDNA (closed circles) or pcDNA vector control (open circles). Each point represents the mean ± standard error (SE) of 3-well replicates. Inset: OATP1B1-mediated uptake (i.e., OATP1B1-pcDNA uptake with the pcDNA vector control subtracted) up to 5 min, fitted with a linear regression line.</div>

Journal of Drug Delivery

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Figure 4

Figure 4: The Signature Sequence Region of the Human Drug Transporter Organic Anion Transporting Polypeptide 1B1 Is Important for Protein Surface Expression 

Figure 4 | The Signature Sequence Region of the Human Drug Transporter Organic Anion Transporting Polypeptide 1B1 Is Important for Protein Surface Expression 