Research Article
The Signature Sequence Region of the Human Drug Transporter Organic Anion Transporting Polypeptide 1B1 Is Important for Protein Surface Expression
Figure 6
Uptake of increasing concentrations of 0.1 μM [3H]E3S + 0–1.5 μM E3S was measured at 37°C after 3 min from (a) OATP1B1 and (b) OATP1B1-FLAG transiently transfected HEK293T cells. The line is the Michaelis-Menten equation fitted to the and . Each point is the mean ± SE of 3 individual experiments with 3-well replicates and the pcDNA vector control uptake was subtracted.
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