Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

Table 2

Coded values and actual values of factor 𝑋₁ and factor 𝑋₂.

Coded Values	Actual Values
	Factor 𝑋1	Factor 𝑋2
−1	10	4
0	15	6
+1	20	8

𝑋₁: concentration of PVA (% w/v of film forming gel).
𝑋₂: number of freeze/thaw cycles.
𝑋₁ and 𝑋₂ are independent variables.
The dependent variables are 𝑌₁, 𝑌₂, and 𝑌₃, where 𝑌₁ is time required for 50% drug release;
𝑌₂ is percent of drug release at 8th hour;
𝑌₃ is “𝑘” of zero order equation.